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Sesquiterpenoids and meroterpenoids from a mangrove derived fungus Diaporthe sp. SCSIO 41011

One new sesquiterpenoid, 1-methoxypestabacillin B, along with one known sesquiterpenoid and six known chrodrimanin-type meroterpenoids were obtained from the solid cultures of a mangrove endophytic fungus Diaporthe sp. SCSIO 41011. Their structures including the absolute configuration at C-6 of compound, were determined by extensive spectroscopic analyses and ECD calculations. Meanwhile, the X-ray crystal structures and absolute configurations of two previously reported chrodrimanins E and H , are described for the first time. All the compounds were examined for HIV latency-reversal and anti-influenza A virus activities.

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